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Home - Products - Others - Other Targets - Difopein TFA (396834-58-5 free base)

Difopein TFA (396834-58-5 free base)

CAS No. ——

Difopein TFA (396834-58-5 free base)( —— )

Catalog No. M30250 CAS No. ——

Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Difopein TFA (396834-58-5 free base)
  • Note
    Research use only, not for human use.
  • Brief Description
    Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.
  • Description
    Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    14-3-3 protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    6501.19
  • Molecular Formula
    C275H425N76F3O91S6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Sequence:{Ser}{Ala}{Asp}{Gly}{Ala}{Pro}{His}{Cys}{Val}{Pro}{Arg}{Asp}{Leu}{Ser}{Trp}{Leu}{Asp}{Leu}{Glu}{Ala}{Asn}{Met}{Cys}{Leu}{Pro}{Gly}{Ala}{Ala}{Gly}{Leu}{Asp}{Ser}{Ala}{Asp}{Gly}{Ala}{Pro}{His}{Cys}{Val}{Pro}{Arg}{Asp}{Leu}{Ser}{Trp}{Leu}{Asp}{Leu}{Glu}{Ala}{Asn}{Met}{Cys}{Leu}{Pro}{Gly}{Ala}{Ala}{Gly}{Leu}{Glu}

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Masters SC, et al. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem. 2001 Nov 30;276(48):45193-200. Epub 2001 Sep 27.
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